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> Kinetin [525-79-1]

Kinetin [525-79-1]

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Referencia orb1224800-200mg

embalaje : 200mg

Marca : Biorbyt


Kinetin

SKU: orb1224800

Description

Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.(In Vitro):Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively.The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.(In Vivo):Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Kinetin

Key Properties

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CAS Number525-79-1
MW215.21
Purity>98% (HPLC)
FormulaC10H9N5O
SMILES9H-Purin-6-amine, N-(2-furanylmethyl)-
TargetOthers
SolubilityDMSO: 8 mg/mL warmed (37.17 mM)

Bioactivity

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In Vivo
Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice. Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant. Animal model: ADP-induced acute pulmonary thrombosis 20-24 g mice (ICR strain). Dosage: 2, 4, 6 mg/kg. Administration: Injection into the tail vein. Result: Reduced mortality to 70%, 40% and 35% at 2, 4, and 6 mg/kg, respectively.
In Vitro
Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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N6-furfuryladenine | NSC 23119
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    Kinetin [orb1306059]

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    C10H9N5O

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    MD 39-AM [orb1304167]

    99.00% (May vary between batches)

    72564-74-0

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    C14H12N4S

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  • 8-Azakinetin riboside

    8-Azakinetin riboside [orb2567141]

    2347524-00-7

    348.31

    C14H16N6O5

    50 mg, 10 mg
  • N-6-Furfurylguanosine

    N-6-Furfurylguanosine [orb1908942]

    99.15% (May vary between batches)

    26783-39-1

    362.34

    C15H18N6O5

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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