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MAT2A-IN-9 [2439277-80-0]

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Referencia NB-64-40968-5mg

embalaje : 5mg

Marca : Neo Biotech

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MAT2A-IN-9

(Synonyms: IDE397, GSK-4362676) Copy Product Info

Synonyms: IDE397, GSK-4362676

Catalog No. T73140 Copy Product Info

Purity: 99.54%

MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of lymphomas and solid tumors.

Cas No. 2439277-80-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.54%

Appearance:Solid

Color:White to Yellow

Product Information

Bioactivity

Description	MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of lymphomas and solid tumors.
Synonyms	IDE397, GSK-4362676

Chemical Properties

Molecular Weight	340.69
Formula	C₁₄H₈ClF₃N₄O
Cas No.	2439277-80-0
Smiles	O=C1N(C=2C(=CC=C(C(F)(F)F)N2)C(N)=N1)C3=C(Cl)C=CC=C3

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9352 mL	14.6761 mL	29.3522 mL	146.7610 mL
5 mM	0.5870 mL	2.9352 mL	5.8704 mL	29.3522 mL
10 mM	0.2935 mL	1.4676 mL	2.9352 mL	14.6761 mL
20 mM	0.1468 mL	0.7338 mL	1.4676 mL	7.3380 mL
50 mM	0.0587 mL	0.2935 mL	0.5870 mL	2.9352 mL
100 mM	0.0294 mL	0.1468 mL	0.2935 mL	1.4676 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

MethionineAdenosyltransferase(MAT)MethionineAdenosyltransferaseMethionine Adenosyltransferase (MAT)Methionine AdenosyltransferaseMAT

Related Tags: MAT2A-IN-9 chemical structure | MAT2A-IN-9 formula | MAT2A-IN-9 molecular weight