Phosphoinositide 3 Kinase, p101, Human, aa8-19, aa838-849 (PI3K)
Referencia MBS659288-1mg
embalaje : 1mg
Marca : MyBiosource
Phosphoinositide 3 Kinase, P101, Human, Aa8-19, Aa838-849 (PI3K) Peptide – Synthetic Peptide, Highly Purified90% by HPLC Purity
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS659288Synthetic (linear) peptides (Ac-CTEDRIQHALER-NH2 and Ac-CYKPEKSDLSSPNH2) corresponding to aa8-19 and aa838-849, respectively, of human PI3 kinase p101. Each peptide has an acetyl group blocking the amino terminus and an amide group blocking the carboxyl… More details
Product Overview
Online Datasheet in PDFProduct Name
Phosphoinositide 3 Kinase, p101, aa8-19, aa838-849 (PIK3R5), Peptide
Full Product Name
Phosphoinositide 3 Kinase, p101, Human, aa8-19, aa838-849 (PI3K)
Product Gene Name
PIK3R5 peptide
Host
Synthetic peptide
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
Highly Purified
90% by HPLC
90% by HPLC
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
97,348 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (8782233..8869029, complement). Location: 17p13.1
OMIM
611317
Product Categories/Family for PIK3R5 peptide
Molecular Biology; MB-Protein Kinases
Applications Tested/Suitable for PIK3R5 peptide
Western Blot (WB)
Application Notes for PIK3R5 peptide
Suitable for use in Western Blot.
Other Notes
Small volumes of PIK3R5 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for PIK3R5 purchase
MBS659288 is a peptide targeting PIK3R5. Also known as Phosphoinositide 3 Kinase, p101, Human, aa8-19, aa838-849 (PI3K). Host: Synthetic peptide.
Additional Details
NCBI/Uniprot data below describe general gene information for PIK3R5. It may not necessarily be applicable to this product.
NCBI Official Full Name
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
NCBI Official Synonym Full Names
phosphoinositide-3-kinase, regulatory subunit 5
NCBI Official Symbol
PIK3R5
NCBI Official Synonym Symbols
p101; FOAP-2; P101-PI3K; F730038I15Rik
UniProt Protein Name
Phosphoinositide 3-kinase regulatory subunit 5
UniProt Synonym Protein Names
PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K
Protein Family
Phosphoinositide 3-kinase regulatory
UniProt Gene Name
PIK3R5
UniProt Synonym Gene Names
PI3-kinase regulatory subunit 5
UniProt Entry Name
PI3R5_HUMAN
NCBI Protein Information
phosphoinositide 3-kinase regulatory subunit 5; protein FOAP-2; ptdIns-3-kinase p101; PI3-kinase p101 subunit; phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
NCBI Summary for PIK3R5
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Show more UniProt Comments for PIK3R5
Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG
By similarity.
Enzyme regulation: Greatly activated by G gamma proteins
By similarity.
Subunit structure: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers. Ref.7
Subcellular location: Nucleus
By similarity. Cytoplasm
By similarity. Membrane; Peripheral membrane protein
By similarity.
Tissue specificity: Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Ref.7 Ref.9
Domain: The heterodimerization region allows the binding to the catalytic subunit.
Involvement in disease: Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9
Show more By similarity.
Enzyme regulation: Greatly activated by G gamma proteins
By similarity.
Subunit structure: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers. Ref.7
Subcellular location: Nucleus
By similarity. Cytoplasm
By similarity. Membrane; Peripheral membrane protein
By similarity.
Tissue specificity: Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Ref.7 Ref.9
Domain: The heterodimerization region allows the binding to the catalytic subunit.
Involvement in disease: Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with PIK3R5 peptide
| Reference Product | PubMed Publications |
|---|---|
| PIK3R1 peptide | >2 publications with PIK3R5 and PIK3R1 |
| PTEN peptide | >2 publications with PIK3R5 and PTEN |
| PIK3CG peptide | >1 publications with PIK3R5 and PIK3CG |
Pathways associated with PIK3R5 peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| 3-phosphoinositide Biosynthesis Pathway antibodies | 3-phosphoinositide Biosynthesis Pathway Diagram |
| 3-phosphoinositide Biosynthesis Pathway antibodies | 3-phosphoinositide Biosynthesis Pathway Diagram |
| Acute Myeloid Leukemia Pathway antibodies | Acute Myeloid Leukemia Pathway Diagram |
| Acute Myeloid Leukemia Pathway antibodies | Acute Myeloid Leukemia Pathway Diagram |
| Aldosterone-regulated Sodium Reabsorption Pathway antibodies | Aldosterone-regulated Sodium Reabsorption Pathway Diagram |
| Aldosterone-regulated Sodium Reabsorption Pathway antibodies | Aldosterone-regulated Sodium Reabsorption Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
Diseases associated with PIK3R5 peptide
| Disease Name | Pubmed Publications |
|---|---|
| Cardiovascular Diseases Antibodies | >1 publications with PIK3R5 and Cardiovascular Diseases |
| Neurobehavioral Manifestations Antibodies | >1 publications with PIK3R5 and Neurobehavioral Manifestations |
| Hematologic Diseases Antibodies | >1 publications with PIK3R5 and Hematologic Diseases |
| Neoplasms Antibodies | >1 publications with PIK3R5 and Neoplasms |