Umifenovir
Referencia M38807-50mg
embalaje : 50mg
Marca : AbMole Bioscience
Quality Control & Documentation
Biological Activity
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro.
Chemical Information
Molecular Weight | 477.41 |
Formula | C22H25BrN2O3S |
CAS Number | 131707-25-0 |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Serap Şimşek-Yavuz et al. Turk J Med Sci. An update of anti-viral treatment of COVID-19
[2] Behnam Amani et al. Immun Inflamm Dis. Efficacy and safety of arbidol (umifenovir) in patients with COVID-19: A systematic review and meta-analysis
[3] Ilad Alavi Darazam et al. Int Immunopharmacol. Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial
[4] I A Leneva et al. Ter Arkh. [Umifenovir and coronavirus infections: a review of research results and clinical practice]
[5] Marzieh Nojomi et al. BMC Infect Dis. Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trial