VDR antibody - N-terminal region
Referência ARP31243_P050
Tamanho : 100ul
Marca : Aviva Systems Biology
VDR Antibody - N-terminal region (ARP31243_P050)
| Datasheets/Manuals | Printable datasheet for anti-VDR (ARP31243_P050) antibody |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human VDR |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 86%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79% |
| Peptide Sequence | Synthetic peptide located within the following region: LKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPV |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-VDR (ARP31243_P050) antibody is Catalog # AAPP31933 |
| Sample Type Confirmation | There is BioGPS gene expression data showing that VDR is expressed in Jurkat |
| Gene Symbol | VDR |
|---|---|
| Gene Full Name | Vitamin D (1,25- dihydroxyvitamin D3) receptor |
| Alias Symbols | NR1I1, PPP1R163 |
| NCBI Gene Id | 7421 |
| Protein Name | Vitamin D3 receptor |
| Description of Target | The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Uniprot ID | P11473 |
| Protein Accession # | NP_000367 |
| Nucleotide Accession # | NM_000376 |
| Protein Size (# AA) | 427 |
| Molecular Weight | 48kDa |
| Protein Interactions | MED12; MED24; BAZ1B; SMARCA4; RXRA; MED1; NCOA2; NSD1; NCOA1; SRPK1; PTPN3; Hr; NKD2; MMRN2; CDCA7L; CXXC5; UBC; RXRB; PRKCSH; PRCP; CFH; CCND3; MYC; MXD1; BRCA1; PSMC5; NCOR1; SRC; NCOA6; PPP1CC; CDK11B; NR1H2; RXRG; CASC4; GABARAPL1; GABARAPL2; CLASRP; |
