Chromosome Enumeration Probes are designed for identification and enumeration of human chromosomes in interphase cells and as an adjunct to standard karyotyping in metaphases. These probes will produce sharp, bright signals specific for each individual chromosome.

As several chromosomes share the same repetitive sequences resulting in cross-hybridization signals, they cannot be differentiated by centromere specific probes. Instead, these chromosomes can be identified by direct labeled Specific Probes hybridizing in close proximity to the respective satellite DNA sequences or to other chromosome specific loci.

The 1p12 Probe is designed to hybridize in close proximity of centromere 1 at 1p12 harboring WARS2 and HA02. Since chromosomes 1, 5, and 19 share the same repetitive sequences, they cannot be differentiated by probes detecting centromere specific repeats.