In situ hybridization centromeric probes - Molecular cytogenetics - Chromosome Enumeration
Chromosome Enumeration Probes are designed for identification and enumeration of human chromosomes in interphase cells and as an adjunct to standard karyotyping in metaphases. These probes will produce sharp, bright signals specific for each individual chromosome.
As several chromosomes share the same repetitive sequences resulting in cross-hybridization signals, they cannot be differentiated by centromere specific probes. Instead, these chromosomes can be identified by direct labeled Specific Probes hybridizing in close proximity to the respective satellite DNA sequences or to other chromosome specific loci.
One of the most common applications of HIS is the diagnosis of chromosomal microremanagements. These are most often specific microdeletions or microduplications of well-individualized clinical syndromes of which the best known are DiGeorge (22q11.2), WAGR (Wilms, aniridia, genital anomalies and mental retardation) (11p13), Williams (7q11. 23) or Smith-Magenis (17p11.2), Prader-Willi and Angelman (15q11q13), Langer-Giedion (8q24) and Miller-Dieker (17p13.3) for deletions, and Wiedeman-Beckwith (11p15), Charcot-Marie-Tooth p(17p12) and Pelizaeus-Merzbacher (Xq22) syndromes for duplications.
Frequently Asked Questions (FAQ)
Where can I find chromosome enumeration products on the CliniSciences website?
What types of products are available in the chromosome enumeration category?
How can I quickly find a chromosome enumeration product?
To find a chromosome enumeration product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.
Does CliniSciences stock several product codes in the chromosome enumeration category?
Yes, CliniSciences distributes several product references in the chromosome enumeration category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.
Can I request a quote for chromosome enumeration products?
Yes, you can request a quote for chromosome enumeration products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.
How can I find out if a chromosome enumeration product is available to order?
The availability of a chromosome enumeration product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.
What should I do if I cannot find the chromosome enumeration product I am looking for?
If the chromosome enumeration product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.
Are all chromosome enumeration products available under the same terms and conditions?
No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.