Translocations involving the immunoglobulin (IG) genes are recurring events of B-cell oncogenesis. In all of these translocations, an oncogene is activated and overexpressed by juxtaposing this oncogene to IG regulatory sequences. Burkitt's lymphoma (BL) is characterized by reciprocal translocations involving the MYC gene and one of the IG loci. The majority of translocations involve the immunoglobulin heavy chain (IGH) locus while a minor part involves the immunoglobulin light chain loci, either the kappa light chain (IGK) or the lambda light chain (IGL). IGK and IGL rearrangements resulting from the variant translocations t(2;8)(p11.2;q24.21) and t(8;22)(q24.21;q11.2), respectively, have been detected in up to 25% of BL cases. In non-Hodgkin Lymphoma (NHL) harboring IG-MYC rearrangements, the MYC translocation partner is IGK and IGL in 8 and 22% of the cases, respectively. IG translocations have been reported in several B-cell lineage malignancies other than BL including atypical Burkitt/Burkitt-like lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and multiple myeloma. Other rearrangement events involve the IGK and IGL gene with the BCL2 and BCL6 oncogenes as translocation partners.