Reagents and instruments for immunology, cell biology and molecular biology.

MDM2 probe for ISH CE/IVD - Gastrointestinal pathology

The MDM2 (MDM2 proto-oncogene) gene is located in the chromosomal region 12q15 and encodes for an E3 ubiquitin ligase which acts as a major negative regulator of the tumor suppressor p53.

Due to amplification of the respective chromosomal region, MDM2 is overexpressed in many human tumors such as soft tissue sarcomas, osteosarcomas, gliomas, NSCLC, gastric and breast carcinomas.

Well-differentiated liposarcomas (WDLPS), the most common soft tissue tumors in adults, are characterized by the amplification of 12q-derived chromosomal material, harboring the MDM2 oncogene while lipomas show balanced translocations involving 12q13-15. Accordingly, detection of the 12q14-15 amplification is regarded as a valuable tool for the differential diagnosis between WDLPS and lipomas.

Furthermore, detection of MDM2 amplification might have prognostic relevance in gastrointestinal stromal tumors (GIST), the most common primary mesenchymal tumor of the gastrointestinal tract.

FISH

Frequently Asked Questions (FAQ)

Where can I find mdm2 products on the CliniSciences website?

mdm2 products are available in this section and can be sorted by product families or sub-categories, such as FISH. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the mdm2 category?

The mdm2 category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The FISH sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a mdm2 product?

To find a mdm2 product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the mdm2 category?

Yes, CliniSciences distributes several product references in the mdm2 category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for mdm2 products?

Yes, you can request a quote for mdm2 products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a mdm2 product is available to order?

The availability of a mdm2 product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the mdm2 product I am looking for?

If the mdm2 product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all mdm2 products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.