Reagents and instruments for immunology, cell biology and molecular biology.
 
Parathyroid hormone

Parathyroid hormone

Parathyroid hormone (PTH) is an 84-amino acid polypeptide hormone produced by the chief cells of the parathyroid glands. As the principal regulator of calcium homeostasis, PTH maintains extracellular calcium concentrations through coordinated actions on bone, kidney, and intestine. The hormone is synthesized as a 115-amino acid preprohormone that undergoes proteolytic processing to generate the biologically active peptide. PTH secretion is tightly controlled by extracellular calcium through the calcium-sensing receptor, ensuring precise regulation via a negative feedback mechanism.

Key Functions and Regulatory Mechanisms

PTH mediates its physiological effects through the PTH/PTHrP receptor, a class B G-protein-coupled receptor expressed predominantly in bone and kidney. Continuous elevation of PTH stimulates osteoclast-mediated bone resorption, releasing calcium and phosphate into the bloodstream. In the kidney, PTH promotes calcium reabsorption while reducing phosphate reabsorption and enhances the synthesis of active vitamin D, thereby increasing intestinal calcium absorption. PTH secretion is regulated by circulating calcium, phosphate, and vitamin D levels.

Research Applications and Clinical Significance

  • Research applications: PTH expression and localization are commonly investigated using immunohistochemistry, immunofluorescence, Western blotting, ELISA, and fluorophore-conjugated antibodies.
  • Clinical relevance: PTH measurement plays a central role in diagnosing hyperparathyroidism, characterized by elevated PTH and hypercalcemia, and hypoparathyroidism, which results in PTH deficiency and hypocalcemia.
  • Therapeutic importance: Understanding PTH physiology supports the development and clinical application of treatments including parathyroidectomy, calcimimetics, and PTH-based anabolic therapies for osteoporosis.

Frequently Asked Questions (FAQ)

How can I quickly find a pth product?

To find a pth product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the pth category?

Yes, CliniSciences distributes several product references in the pth category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for pth products?

Yes, you can request a quote for pth products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a pth product is available to order?

The availability of a pth product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the pth product I am looking for?

If the pth product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all pth products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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