Ulex europaeus Lectin (UEA I)

Ulex europaeus Lectin (UEA I)


Ulex europaeus agglutinin (UEA I) is isolated from gorse seeds. It has a molecular weight of 63 kDa that consists of two subunits and has an isoelectric point between pH 4.5 and pH 5.1. The lectin is a glycoprotein that has no mitogenic activity and agglutinates type O erythrocytes, and of a lesser degree to individuals with A2 erythrocytes.
UEA I has a carbohydrate specificity for L-fucose and elutes with the sugar L-fucose. The lectin reacts strongly with alpha(1,2) linked fucose residues but poorly or not at all with alpha(1,3) or alpha(1,6)-linked fucose. UEA I is unable to bind internal fucose structures and the presence of an internal alpha(1,3)-linked fucose on the H type 2 oligosaccharide decreases lectin affinity for this blood group antigen by 3-fold.
UEA I has been used as a marker for vascular endothelium and used to identify endothelial cells of benign vascular lesions more specifically than antibodies of Factor VII-related antigen. UEA I coated magnetic beads have been used to isolate endothelial cells associated with micro-vessels for subsequent cell culture. This lectin has also been used to differentiate between angiosarcomas and epithelial tumors.

Lista de productos

Referencia
Descripción
Tamaño
Precio excl. IVA
Nombre de resultados por pàgina : 10 50 250