Reagents and instruments for immunology, cell biology and molecular biology.

Beta-D-glucopyranoside series

Often the first choice and, coincidentally, the most popular detergents for membrane protein work are non-ionic, sugar-based detergents, mostly derived from maltose or glucose. These detergents are mild and non-denaturing because they disrupt protein-lipid and lipid-lipid interactions rather than proteinprotein interactions. The sugar serves as a polar head group with a non-polar alkyl chain attached. The hydrophilic head groups offer ample strength to extract proteins while still providing the capability to stabilize proteins in solution and promote crystal growth. These detergents are also well chronicled for their ability to stabilize other large macromolecules as well.

These micelle-producing detergents are perfect for both protein extraction and maintaining solubility and stability in aqueous environments. Glucoside detergents have a long track record of crystallizing membrane proteins for x-ray crystallization studies or creating the necessary stable tertiary structure for NMR work. Anatrace detergents are the most cited detergents in journal articles pertaining to structure and function of membrane proteins.

The use of D-glucopyranoside derivatives as detergents for membrane proteins is a well-established practice in biochemical and biophysical studies. These detergents are part of the broader class of non-ionic detergents and are selected for their ability to solubilize membrane proteins while maintaining their native structure. Here are some notable members of the beta-D-glucopyranoside series commonly used as detergents for membrane proteins.

Frequently Asked Questions (FAQ)

How can I quickly find a beta-d-glucopyranoside series product?

To find a beta-d-glucopyranoside series product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the beta-d-glucopyranoside series category?

Yes, CliniSciences distributes several product references in the beta-d-glucopyranoside series category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for beta-d-glucopyranoside series products?

Yes, you can request a quote for beta-d-glucopyranoside series products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a beta-d-glucopyranoside series product is available to order?

The availability of a beta-d-glucopyranoside series product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the beta-d-glucopyranoside series product I am looking for?

If the beta-d-glucopyranoside series product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all beta-d-glucopyranoside series products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.