In situ hybridization probes - Genetics
Karyotyping is the isolation, staining and visual examination of chromosomes to find chromosomal rearrangements. Karyotyping is used in prenatal diagnosis (particularly amniocentesis for trisomy 21), investigation of repeat pregnancy loss, investigation of children and adults with features suggestive of a syndrome (dysmorphic features or other associated anomalies, mental retardation, learning disabilities or behavioural anomalies), and subtyping of lymphomas, leukemias and solid tumours for the purpose of exact diagnosis, treatment stratification and prognosis.
Resolution of very small deletions (microdeletions) and small translocations is possible with in situ hybridization (ISH).
The potential of ISH to detect much smaller chromosomal abnormalities than can be detected with karyotyping has already been mentioned. ISH does not require cells to be in the metaphase before analysis, because it relies upon the presence or absence of a fluorescent signal to identify chromosomes or parts of chromosomes, rather than a specific banding pattern. It allows the surveillance of more cells and requires a much smaller sample than karyotyping — even down to a single cell.
Frequently Asked Questions (FAQ)
Where can I find genetics products on the CliniSciences website?
genetics products are available in this section and can be sorted by product families or sub-categories, such as Molecular cytogenetics. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.
What types of products are available in the genetics category?
The genetics category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The Molecular cytogenetics sub-categories allow you to find the products that meet your needs more quickly.
How can I quickly find a genetics product?
To find a genetics product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.
Does CliniSciences stock several product codes in the genetics category?
Yes, CliniSciences distributes several product references in the genetics category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.
Can I request a quote for genetics products?
Yes, you can request a quote for genetics products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.
How can I find out if a genetics product is available to order?
The availability of a genetics product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.
What should I do if I cannot find the genetics product I am looking for?
If the genetics product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.
Are all genetics products available under the same terms and conditions?
No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.