Specifications

Product Data
Clone Name	6D499
Applications	FC, IHC
Recommended Dilution	Flow Cytometry. Immunohistochemistry on Paraffin Sections: 2.5 - 5 µg/ml.
Reactivities	Human
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Immunogen	L1.2 cells expressing Human Interleukin-8 Receptor type B (IL8RB).
Specificity	This antibody recognizes Interleukin 8 Receptor B (CXCR2/IL8RB).
Formulation	PBS without preservatives. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage	Store the antibody undiluted at 2-8°C for one month or (Add 40-50% Glycerol) at -20°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Gene Name	C-X-C motif chemokine receptor 2
Database Link	Entrez Gene 3579 Human UniProt ID P25025
Background	CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
Synonyms	CXCR2, CXCR-2, GRO/MGSA receptor, IL-8 receptor type 2, CDw128b, IL8 receptor beta
Reference Data